Sunday, October 30, 2016

Science Is Rooted To All Things

Austin Maddox
Professor J. Karpel
Biology of Disease
OCT 28 2016
Science Is Rooted To All Things
The saying that all roads lead to Rome holds true in science; science has its roots in the source to all concepts and ideas, its connected in one way or another to all fields of endeavor. In my personal life, I am involved in two major fields of endeavor: medicine, and search and rescue. I have found through all of my passions that science; physics, biology, chemistry you name it, can be used as a tool to solve any problem. Let’s start with the field of medicine.
MEDICINE
I have worked in the medical field for a good portion of my life; in this field I have seen life, death, and all sorts of trauma. Of the events I have encountered both professionally and personally have been solved with science. In the field of medicine we use evidence based practice to further progress and better our patients. Evidence based practice (EBP) is the conscientious, explicit and judicious use of current best evidence in making decisions about the care of the individual patient. It means integrating individual clinical expertise with the best available external clinical evidence from systematic research to further the patients care and provide life-essential care. Over the past month we have gone over brain and GI disorders and how they are linked, all of these conditions are also linked to medicine. Lets’ take for example ADHD: break it down into its components; diagnosis and medical treatment. What is ADHD? ADHD is an attention deficit hyperactivity disorder; in a nutshell it makes an individual have a hyperactive brain, somewhat short attention span, and at times impulsive (American Psychiatric Association).
Diagnosis for this disorder is taken by scientific observational behavior analysis. They look at the behaviors and link the behaviors to areas of the brain, functions, and chemicals involved with these behaviors. The main chemicals involved with ADHD and its effect on the brain are dopamine and noradrenaline. The imbalance of these two chemicals lead to delayed maturation of dopaminergic pathways as well as influencing impulsivity and inattention. Emerging evidence also suggests possible roles for other signalling systems in the neurobiology of ADHD. Deficiencies in glutamate signalling in some regions of the brain may have a modulatory role in adults with ADHD (Winstanley).
Electrical brain activity also plays a vital role in diagnosis of ADHD. Using qualitative electroencephalography (EEG) from world-wide studies. In these studies it showed an increase of theta and beta brain wave frequency bands on the EEG. (Loo) Beta waves are high frequency low amplitude brain waves that are commonly observed while we are awake. They are involved in conscious thought, logical thinking, and tend to have a stimulating affect. Having the right amount of beta waves allows us to focus and complete school or work-based tasks easily. People with ADHD tend to have low frequencies of beta waves which lead to poor cognition and spaciness. Theta waves frequency range is involved in daydreaming and sleep. Theta waves are connected to us experiencing and feeling deep and raw emotion as well as has its benefits of helping improve our intuition, creativity, and makes us feel more natural. People with ADHD tend to have high frequencies of theta waves; this is what attributes to their hyperactivity, impulsivity, and inattentiveness (Snyder).
 All of the background diagnosis through scientific methods of observation and exploration has led to various medicinal EBPs to help people cope and deal with the disorder to live healthy lifestyles. Most medication for ADHD are neuro-stimulants that normalize chemical imbalances and increase/decrease brain wave frequencies (Arns). In my personal experience these stimulants aided in increased focus and decreased impulsivity. They come up with these medicines through the science of biochemistry. So again science has its roots in all things, especially medicine.
Throughout my college career at SUU I have worked with Iron County search and rescue. In this time, I have seen many criminal and forensic sciences used. For example, during the Hildale flood incident search and rescue had to use techniques to identify bodies of persons lost in the flood.  Again, science has its roots in all things, including search and rescue. There was a lot of anatomy involved in identifying the victims. Using their facial structures to create reconstructions, to simply looking at overall body markers and structure make a huge difference and help in identifying the victim.
Another way that science is used in search and rescue is to find people. Having a knowledge of how weather influences location and the effects of environment on a person can be key in finding missing people, and before it is too late. Knowing that high temperatures, combined with lack of potable water can cause a person to dehydrate after so many days, or that the latest rainstorm caused severe flooding which could have affected the missing person’s location. Knowing the geography of the area you are searching is helpful in pinpointing the route that the missing person may have taken to try to get to safety. While there are so many examples that can be used, I think it is clear to see again that science has a root in all things.
So, just like all roads lead to Rome, science can be found in so many aspects and endeavors of our lives. While it may not be as blatantly obvious in some over others, it’s there, and plays a key role in that endeavor. Being able to notice the use of science in our endeavors, and appreciate it’s necessity, allows us to become more well-rounded as scientists, and individuals.


REFERENCES
American Psychiatric Association. (2013). Diagnostic and statistical manual of mental disorders: DSM-5, Washington, D.C.: American Psychiatric Association
Arns, M. (2012). EEG-based personalized medicine in ADHD: Individual alpha peak frequency as an endophenotype associated with nonresponse.Journal of Neurotherapy, 16(2), 123-141.
Bader, A. & Adesman, A. (2015). Complementary and alternative medicine for ADHD. In R.A. Barkley (Ed.), Attention Deficit Hyperactivity Disorder: A Handbook for Diagnosis and Treatment (pp. 728-738). New York: Guilford Press.
Loo SK, Makeig S. Clinical utility of EEG in attention-deficit/hyperactivity disorder: a research update. Neurotherapeutics 2012; 9: 569-587.
Snyder SM, Hall JR. A meta-analysis of quantitative EEG power associated with attention-deficit hyperactivity disorder. J Clin Neurophysiol 2006; 23: 440-455.

Winstanley, C. A., Eagle, D. M., & Robbins, T. W. (2006). Behavioral models of impulsivity in relation to ADHD: translation between clinical and preclinical studies. Clinical psychology review, 26(4), 379-395.



Saturday, October 29, 2016

Brains and Guts at the End of October

Connor Mooney

The world we live in today requires those in it to push to be excellent in their fields of endeavor. It isn’t surprising, then, that there is a big focus on physical and mental wellbeing. It also surprises few that these parts of our lives are intimately connected. It’s a popular science project that elementary age kids do for science fairs (personal experience: I’ve judged several science fairs, and this one always seems to pop up) where they give math quizzes to kids who finished playing outside and compare their performance to when they didn’t go outside. The kids who had just finished exercising (recess) always perform better on their math quiz. It is also well known that mental illness and brain injury have varied systemic effects as well. The purpose of this article is to explore the effects that mental and gastrointestinal (or GI) issues has on those in various fields of endeavor.

The first field of endeavor to look at is that of a drunk. I know not many in our society would endeavor to be a drunk, but in certain circles of friends, the ability to drink more than others is celebrated and grounds for gloating. One of the issues with alcohol, though, is that it is a poison. Fortunately for drunks, though, mammals have what’s called the area postrema, a part of our brain stems that has no blood-brain barrier that monitors the contents of our blood and induces vomiting when an emetic compound is present. Mothers also may have cause to hate their area postrema because it interacts with hormones and is thought to cause morning sickness

In addition to the drunks, we all use connections between our brains and our guts to maintain regular flow of food through the GI tract. It’s modulated by the brain through the Vagus (Li & Peng, 2014) nerve that connects to a cluster of nerves that is referred to as the pancreatic brain which is the head of the Enteric Nervous System that governs much of GI function.

One field of endeavor that we often overlook is the role of a stay-at-home parent. This role is all the more important if there is a disabled child in the family. However, the connection I’m looking to make here is between a stay-at-home parent and Huntington’s disease. There’s a lot of things that can happen that change a family dynamic, and any chronic disease or illness is a clear and present threat to many families. It can tear families apart as I discussed in the last group of entries, or it can bring them together. Every family is different, and counseling or, at the very least, education is often offered (Wagner et al., 1996). Unique challenges present themselves. Massive lifestyle changes are associated with diagnoses, especially that of Huntington’s disease. The diagnosis is almost a death-sentence. The patient has a limited amount of time to spend before he/she loses his/her mind and ability to control their own movements. How would they spend this time? Vacationing with family? Pursuing other avenues of pleasure? Continuing to work and spend time with their children? Drop everything and start cooking meth a la Walter White? It’s ultimately the patient’s choice how to spend their last cognizant years, but with Huntington’s, due to its normally late diagnosis, it’s more likely that they will have a family that they unknowingly dragged into the mix. There could very well be warning signs to prepare the patient for this lifestyle crossroads. The fact that it’s autosomal dominant means that if they have a parent who had the disease, they have a 50-50 chance of getting it, too. They could get tested and make the preparations necessary for their future. What effect does this have on the stay-at-home parent? It means that the patient can no longer provide the services for his/her family, and somebody has to work and provide for the family as well as pay the medical bills which are substantial (Divino et al., 2013). Stay at home parents can’t stay at home anymore when their spouse reaches the later stages of the disease, and if it is the stay-at-home parent who reaches that point in the disease development, measures must be taken to fulfill the roles he/she played in the home. It’s often a nightmare for the family due to the psychological decline that comes with the disease (Vamos et al., 2007), and we ought to find out how we can better treat this disease that is so traumatic to family members.

Educators, especially those of young children, have a very important role in our society, and it is a position that many endeavor to have. An issue that we have recently had a boom in is that of children with Attention Deficit Hyperactive Disorder (ADHD). It has been a bit of a controversy in that some believe that the disorder is now being recognized more often in children while others believe that it is an excuse for poor parenting technique and relying on the drugs treating it to make their job easier. There are a huge amount of factors that contribute to the advancement of ADHD. These indeed include poor parenting (pre-, peri-, and postnatal care), a number of gene alleles, and anatomical variation (Curatolo et al., 2010). It is unfair to the parents of afflicted children to assume that it is their fault, but it shouldn’t be completely ignored as a possibility for making it worse. Teachers have a unique challenge of maintaining order in a classroom full of many children who tend to be active regardless of whether they have ADHD or not. Children come from a variety of backgrounds and home environments, and sometimes, unfortunately, these kids may suffer from several different issues that may manifest themselves in various manners. ADHD, being one of these, may be one of the most problematic and frustrating. The disorder is treated with stimulants which may seem counterintuitive, but the explanation stems from arousal theory. When under-stimulated, patients with ADHD tend to move or distract themselves to raise their arousal by focusing on several different things. So when the children take the drugs, such as Adderall (an amphetamine), their minds are aroused to the point where they can focus much better on schoolwork.

Psychiatry has come a long ways since the hospitals were taking care of the mentally ill by using corporal punishment and other inhumane treatment. It used to be that the mental hospitals were filthy areas used to babysit people who were considered ill in the mind. I first learned of the reality of this dark piece of our history in my Sociology 1010 class, and ever since, the media has reminded me in movies such as Sucker Punch, 12 Monkeys, and One Flew Over the Cuckoo’s Nest and TV shows like American Horror Story: Asylum. These shows misrepresent mental illness by showing that the afflicted are mostly dangerous, scary or evil. The reality is that there are several severities of various mental illnesses, and the lack of treatment that often accompanies the portrayal of these scary asyla can make the condition much worse. My sister works in a Long-Term Care wing of my hometown’s hospital. She refers to her patients (most are mentally ill) with great affection as though her patients are her friends, which many of them are. One of the sad things that she has expressed to me is that there are things that the nurses and aids need to do that would embarrass anyone involved in such procedures. Naturally, said procedures are met with any level of resistance. It’s a sad conflict that results in more than blushing, and sometimes as much as a feeling of violation in the patient. Some media have taken advantage of such situations by making the caretaker seem like a mean spirited or evil individual when in fact they are doing their job. I propose that Hollywood ought to make an unbiased real and true account of our modern psychiatric hospitals. In doing so, the public may be more thoroughly informed about the state of our country’s psychiatric field. I think we would see that we have advanced quite a ways from the beginnings of institutionalization of the “disturbed” in decaying buildings that facilitate the corporal punishment of anyone not behaving.

My sister often discusses the irritation that she feels when dealing with the mentally ill, and I know she’s a good CNA, but sadly there are many that aren’t. A psyche nurse in a large hospital spoke to the writers of Cracked.com and told his story of how he was pressured into mistreating the residents of the psyche ward in the hospital. The sad part is that by the time he stood up and reported the mistreatment, the people he worked with who mistreated the residents more regularly felt betrayed by him, and refused to help when the residents began to get violent. This is something that really shouldn’t be happening at all in places entrusted with the care of people’s family members. Not only this, but really there ought to be legislature to prevent this from happening or, at the very least, elevated security and counseling for hospital employees.

Moving on to the gastrointestinal tract, the food industry is often the butt of many jokes when it comes to the health of consumers. Whether it be complaints about the lack of healthy options at McDonald’s or the hippie jokes regarding Whole Foods, there’s always a quip to elicit a giggle. However, the beauty of the free-market system that we have is if you don’t like something about the establishment, you don’t have to eat there. Consumers drive the quality and the diversity. My point in saying this is the fact that unhealthy fast foods like McDonald’s, Burger King, KFC, and the like are so popular is because we made them that way. The big mac, whopper, and that sandwich that used fried chicken as the buns, all became hot button because of the consumers at the time of its coming out. More recently, there has been a movement (likely due to earlier generations feeling the effects of their unhealthy lifestyles and the rise in childhood obesity) to make the fast food healthier. Wendy’s has salad choices, McDonald’s offers milk and apples in place of soda and fries in their Happy Meals, and KFC got rid of that God-awful “sandwich”. So we’re moving in the right direction, but is it enough? Several studies have shown that red meat tends to contribute to the development of colon cancer (Harvard Health Publications, 2008). If people get mad about their obese children, it’s only a matter of time until customers ask that they reduce the number of beef options in these popular restaurant chains. At the same time, beef has been shown to have a number of redeeming qualities: high iron content, folic acid, Zinc, Vitamin B­12, and a whole lot of protein. In the end, I think it’s still up to the consumer to choose a healthy lifestyle. In a world like today’s it’s a tough road to take, but really, if we want to shed the problems associated with overeating and poor diet, it is a case by case issue where each person must choose the healthier option.

The anti-gluten movement in my personal opinion is being taken a little overboard since it was brought to everyone’s mind through publicity of Crohn’s and celiac disease. One question that I have concerning the movement is what is its effect on the agriculture industry? In The New Yorker (Specter, 2014), Michael Specter explains a shift in wheat consumption by the masses. He explains the vast amount of wheat that is produced by wheat farms across the nation are used in far more than just breads, cereals, and pastas. Some of it, including proteins isolated from it (like gluten) or starch, has become a big part of the other foods we eat (Specter says almost a third of our food contains these components of wheat). According to one of his sources, Joseph A. Murray (a professor of medicine at the Mayo Clinic), consumption of wheat has been decreasing over the past 50 years. This doesn’t necessarily mean wheat farmers’ families are going hungry. It’s more likely that the farmers simply shift crops. Wheat is a grass, after all, it may change the soil, but I imagine that growing another grass-like plant (corn for example) would be a relatively simple switch. The backlash against the gluten madness may be greater than just agriculture, though. His article is a little blog-ish, but Hank Campbell (the president of the American Council on Science and Health) posted his comments on the issue on his site, Science 2.0 (Campbell, 2013). He worries that there are many people adopting a gluten-free lifestyle despite the fact that they don’t have celiac disease. He also brings up the fact that many in the food industry may be going “gluten-free” or at least offer gluten-free alternatives while they replace it with ingredients like “extra sugar, extra fat, hydroxypropyl methyl cellulose and xanthan gum.” He also brings up the fact that politicians are ever eager to shove their noses into businesses with unnecessary regulations such as the prospective ban on trans-fats, GMO’s, and perhaps the staple of people’s food, gluten. It’s up to us to decide what’s good for us. We don’t need others dictating our home menus.

It’s important that everyone educate themselves a little bit on what possible issues will arise in their field of endeavor. Everyone works in either their dream job or some other job that they have to get money to do the things they want to do. The problem is that we fall into a routine and we don’t take into account possible things that could happen as we wait for our next coffee break. The beauty of a scientific mind is that it gives the opportunity to open your mind to other possible explanations and issues. I think everyone would benefit from a little science in their life and consider what can go wrong.




References

Campbell, H. (2003) The Gluten-Free Fad is Dangerous – So is the Backlash. Science 2.0 URL: http://www.science20.com/science_20/glutenfree_fad_dangerous_so_backlash-124085
Curatolo, P., D’Agati, E., & Moavero, R. (2010) The Neurobiological Basis of ADHD. Italian Journal of Pediatrics. 36:79
Divino, V., Dekoven, M., Warner, J.H., Giuliano, J., Anderson, K.E., Langbehn, D., Lee, W.C. (2013) The Direct Medical Costs of Huntington's Disease by Stage. A Retrospective Commercial and Medicaid Claims Data Analysis. Journal of Medical Economics. 16(8):1043-1050. doi: 10.3111/13696998.2013.818545.
The Family Health Guide. (2008) Red Meat and Colon Cancer. Harvard Health Publications. URL: http://www.health.harvard.edu/family-health-guide/red-meat-and-colon-cancer
Li, Q., & Peng, J. (2014) Sensory Nerves and Pancreatitis. Gland Surgery. 3(4):284-292 doi:  10.3978/j.issn.2227-684X.2013.10.08
Specter, M. (2014) Against the Grain: Should You Go Gluten-Free. The New Yorker. November 3, 2014 issue.
Strusiewicz, C.J., & Anonymous (2016) Things I Saw as a Psych Ward Nurse Too Dark for Horror Films. URL: http://www.cracked.com/personal-experiences-2365-i-was-psych-nurse-who-abused-patients-with-chokeholds.html
Vamos, M., Hambridge, J., Edwards, M., Conaghan, J. (2007) The Impact of Huntington’s Disease on Family Life. Psychosomatics. 48(5):400-404 doi: 10.1176/appi.psy.48.5.400

Wagner, E.H., Austin, B.T., Von Korff, M. (1996) Organizing Care for Patients with Chronic Illness. The Milbank Quarterly. 74(4): 511-544

Friday, October 28, 2016

A Prescribed Epidemic

I grew up in a small town near the Utah/Idaho border called Fielding. The small town lifestyle often includes knowing a lot about the people around you and after being there for 18 years, there are few unfamiliar faces. I had a good friend in the next town over that I did many things with throughout high school. We played baseball together and we had the opportunity to play ball all over the country. Both of our families appeared 100 percent normal to most people from the outside and our families became quite close over the years. My friend’s parents ran a sod farm that provided grass implants to many of the surrounding areas and they did very well. One day, after I had known this family for some time, I learned a very sad and resounding story about the family that I never would have thought possible. As with many of the people in our town, we affiliated with the predominant LDS church and I always thought everyone in this family was just the same old friendly do-gooders that was so common in the area. In fact, I knew for a fact that the father in the family had been a bishop in the local ward. The story starts with his father whose name was Dee. As previously mentioned, he was in charge of a sod farm and was a hardworking self-made man. However, I learned that he had stepped down from running the farm and had begun work at an addiction treatment center for our local valley. It wasn’t long after that I heard that he had actually been arrested a couple of years previously while he was still a bishop in the church. In fact, he was taken away and put in handcuffs during the Sunday meetings that he was conducting. It was then I learned that Dee was suspected of breaking into numerous houses throughout his neighborhood trying to get his hands on a prescription drug that we know so well: Oxycodone. Eventually, enough evidence came about for there to be a warrant for his arrest. As you would expect, this type of news is unexpected and quite alarming to hear especially when you have grown close to someone. Dee was not a bad person by any means. I later learned that he initially injured himself when a ladder slipped out from underneath him while working on the roof of his house. His back pain would not go away and he went to a doctor who prescribed the opioid Oxycodone to him. When the pain didn’t go away he went back to get more of the drug until the doctor would no longer give him any. He then resorted to stalking the pharmacy to learn what people might have the drugs he needed and then blatantly robbing them of the drugs when he got the chance. 
            This is only one story in a larger problem that is in our hands today. Thankfully, Dee is back to living a normal life and is trying to work with others who have had similar problems. He has been working at the addiction center for quite some time and from what I hear he is a fantastic resource for the center. However, it seems like more and more of the stories that are similar to Dee’s are not ending with a happily ever after. According to the CDC, 46 people die from prescription painkiller overdoses each day. Additionally, in 2012, health care providers wrote 259 million prescriptions for painkillers. That’s enough for each citizen in the United States to have their own bottle of pills (Opioid Painkiller Prescribing 2014). Even more alarming, the National Institute on Drug Abuse (NIDA) estimated that 7 percent of patients who are prescribed narcotics or opioids designed to treat all kind of pain become addicted to them—that amounts to 2 percent or 4.7 million people who are addicted to some kind of opioid throughout the United States (Yoder 2015).
These statistics get even scarier when we start to include heroin use in the mix. Heroin is also an opioid, but it is sold on the street and is highly illegal to possess or sell. In the past decade, heroin use has increased 300 percent in the United States and the largest single increase has been in the age 19 to 25 demographic of the population. Prescription drug users are also 40 times more likely to use heroin as well (Todays Heroin Epidemic 2015). If a prescription user is unable to get a new prescription from their doctor prescribed they often turn to the cheaper, illegal, and even more deadly heroin to live out their addiction. All opioids have the property that eventually induces a tolerance in the user over time which is the cause to most of the unintentional overdoses that we hear of all the time.  I had a cousin who had this very thing happen to him. He got into hard drugs at an early age, but was able to rehab and get clean for around a year. He had improved and had started a family when he relapsed, but when he took the same dosage that he had been taking before he got clean his body couldn’t take it and he died leaving two kids behind. His body no longer had the tolerance that it had when he was a regular user. Heroin is becoming more and more available to addicts as well. Since there has been a growing number of reports detailing prescription drug abuse, some measures have been taken to limit the number or type of prescriptions that a physician can give to patients. However, that hasn’t done anything to stop the amount of people getting addicted to the drugs. As the drugs become harder to get, the illegal use of heroin becomes more of a viable option. There is compiling evidence to support that heroin is slowly growing in popularity as opioids are slowly getting harder to get (America’s Addiction to Opioids: Heroin and Prescription Drug Use 2015).
The science behind drug abuse and addiction is heavily studied, but rarely well understood by the common person. Many experts suggest that a person’s vulnerability is based largely around their genes. Other factors include external environmental factors or certain disorders. The important fact to me though is realizing that this problem is not always something that is controlled. Sure, the initial choice to use a drug is usually a choice (or a choice given by a medical professional), but we really need to start looking at drug addiction as a full scale disease that we need to treat in a variety of ways. Addiction, according to the NIDA is defined as a chronic, relapsing brain disease that is characterized by compulsive drug seeking and use, despite harmful consequences (Drug Abuse and Addiction 2014). All synthetic drugs either trick the brain into believing that they are a natural neurotransmitter (opioids) or cause an abnormally large amount of the neurotransmitter to be released (amphetamines). All of them create a euphoric effect that make our brain think that a life sustaining activity is occurring. Since our natural instinct is to sustain our lives, the brain wants to keep doing the activities that give it pleasure. Dopamine, the most common chemical associated with drug addiction, is released in extremely high concentrations when drugs are used. While it is natural in our bodies, when released due to drug use, as much as 10 times the amount is released when compared to other natural releases that occur during things like eating, sex, or physical activities (Drug Abuse and Addiction 2014). After a while the user needs the drug just to feel normal and they become a slave to the drug.
After reading all these statistics coupled with my own real world experiences, I have to wonder what more can we do to help prevent these types of things. While unfortunately there is no perfect solution, I believe that there are several things that can take place that will help reduce the plague that opioid use has become throughout the world. First and foremost, we need to limit the amount of prescriptions that are given out by doctors. This is not to say that doctors are all irresponsibly prescribing medications, but I definitely believe that many prescriptions are given in order to appease both the patient and to get the next customer in the door as soon as possible. If someone is in pain and an alternative option is available, then the alternative should always be first. The healthcare system needs to realize that there are other options available in this modern age. For example: utilize chiropractors, free physical therapists from the restraints of secondary care, promote acupuncture, realize that naturopathic doctors have a place in the healthcare system. If insurance would cover more alternative medical techniques, people would use these other options more. The fact is there are many different ways to treat pain, but insurance companies won’t cover anything except prescription drugs.
Secondly, the big pharmaceutical companies are happy to allow that to keep happening since their pockets remain full, but they too need to be held responsible for the damage they might be causing. The pharmacy industry is full of shady characters who will do whatever they can to sell their products. The most famous example of this in terms of opioids was the case in 2007 in which the company Purdue Pharma was sued for $600 million dollars for misleading authorities, doctors, and customers about the addictive nature of their drug OxyContin. They were guilty of promoting the drug to doctors while misleading them on the signs of drug addiction (Meier 2007). I know how rigorous the testing process is to get drugs from the laboratory to the consumer are, but there needs to some way to make the manufacturing companies more responsible. I’ve never understood why big pharmacy companies are allowed to advertise their products as freely as they do. I think it’s a big reason that our society is getting so comfortable with prescription drugs in the first place. They hear an ad on TV that claims to cure some disease just by popping a pill and they think that any disease can be cured that way. Additionally, companies often have the audacity to tell consumers through advertisements to recommend certain drugs to their doctor. I might be crazy, but shouldn’t it be the other way around?
The final, and likely most beneficial solution to the opioid epidemic, is to be release medical marijuana from its current state of legislation. We need to remove the stigma that has been placed on this drug over the years and tap into the potential that it has. While the jury might still be out on whether recreational marijuana is a smart go, the utility for the drug to help with the opioid epidemic is clear.  The momentum in favor of using marijuana as a pain treatment is finally starting to gain a little steam this year as a group in Maine has asked legislatures to consider marijuana as a suitable treatment for pain (Graham 2016). Other studies have come out detailing the facts that states that have voted to loosen laws on marijuana already see 25 percent decreases in opioid overdoses since the drug was decriminalized (Sifferlin 2016). The evidence is building as research has seen uses for cannabis in treating the symptoms of ailments such as Crohns disease, nausea from cancer, hypertension, sleep apnea, and a growing list of ailments (Illnesses Treatable with Marijuana 2016). On top of all of the medical benefits, there are additional reasons to rethink how marijuana is legislated. The cost of opioid abuse costs an estimated $75 billion dollars each year in the United States alone (Sifferlin 2016).  Imagine eliminating 25 percent of that and having that money repurposed somewhere else in our economy. The money that we could be making from marijuana brings about a completely different argument in this discussion. If we were to bring in the money that recreational use of marijuana would bring into our country, there would be a multitude of reasons to loosen laws as well. We will see what happens in the near future, but I hope that future legislation allows medical marijuana to become a mainstream thing. To me, it’s a no brainer to make use of a much less harmful substance that can do a lot of good.
Action starts with education and I feel like more people need to be aware about what is going on with opioid abuse in our country.  It seems like most people I know have a story similar to my stories of Dee and my cousin. I hope that we can raise awareness about the subject and keep young people from becoming addicted to hard drugs that are legally prescribed to them. I hope that we can find more uses for alternative medicine in our healthcare system and see that insurance companies cover them. This way the alternative methods can be used more frequently and without as many worries about the costs of such treatments. Pharmaceutical companies should also take part in the responsibility and not try to push addictive drugs into the mainstream so much. They will make enough money as it is and don’t need to create addicts out of their consumers to make a profit. While the full extent of the health benefits is being studied, I hope that everyone can give more thought to the uses of medical marijuana practice in our country as well. A lot of damage has already been done because of prescription drug abuse and I hope to see the problem reduced sometime in the near future.
Works Cited

"America's Addiction to Opioids: Heroin and Prescription Drug Abuse." National Institute on Drug Abuse (NIDA). N.p., 14 May 2014. Web. 27 Oct. 2016.
"Drug Abuse and Addiction." National Institute on Drug Abuse (NIDA). N.p., n.d. Web. 28 Oct. 2016.
Graham, Gilliam. "Advocates Ask Maine Regulators to Consider Marijuana to Treat Opioid Addiction - The Portland Press Herald / Maine Sunday Telegram." The Portland Press Herald Maine Sunday Telegram Advocates Ask Maine Regulators to Consider Marijuana to Treat Opioid Addiction Comments. N.p., 20 Apr. 2016. Web. 28 Oct. 2016.
"Illnesses Treatable With Medical Cannabis." United Patients Group. N.p., n.d. Web. 29 Oct. 2016.
Meier, Barbara. "In Guilty Plea, OxyContin Maker to Pay $600 Million." New York Times. N.p., 10 May 2007. Web. 27 Oct. 2016.
"Opioid Painkiller Prescribing." Centers for Disease Control and Prevention. Centers for Disease Control and Prevention, 01 July 2014. Web. 27 Oct. 2016.
Sifferlin, Alexandra. "Can Medical Marijuana Help End the Opioid Epidemic?" Time. Time, 28 July 2016. Web. 28 Oct. 2016.
"Today’s Heroin Epidemic." Centers for Disease Control and Prevention. Centers for Disease Control and Prevention, 07 July 2015. Web. 27 Oct. 2016.
Yoder, Written By Robert. "Adults Addicted to Painkillers." The Palm Beach Institute. N.p., 02 Nov. 2015. Web. 27 Oct. 2016.

Bacteria Buddies

Beneficial Bacteria

    There are more bacteria in the human gastrointestinal tract than there are actual human eukaryotic cells in the body (Sudo, 2004). The thought of this is probably enough to make most people feel unsettled. The real truth is most bacteria are not pathogenic and are actually helping our body. This natural colonization of microbes in the gastrointestinal tract is referred to as the gut microbiota (also referred to as the gut flora). The microbes provide several benefits including prevention of pathogenic bacteria from entering the gut epithelium, breaking down of macronutrients for absorption, immune function maturation, vitamin K production, development of the brain-gut axis, and many others. With all these benefits, the survival of these microbes becomes very essential for our health.

    The gut microbiota colonize and develop in humans immediately after birth (Del Chierico, 2015). This is a crucial period for the development of these bacteria and is guided by genetics, antibiotic use, breastfeeding, and delivery method (C section vs vaginal). Disruption in colonization can lead to many problems in early childhood and adulthood. One of these problems occurs in the development of the immune system. The immune system is dependent upon these early bacteria to develop and mature properly. One example is the development of gut-associated lymphoid tissues (GALT). If early microbial development is delayed, GALT doesn’t develop properly and leads to an increased likelihood of developing a GI disease (West, 2015). The gut microbiota has also been found to aid in the maturation of Th1 and Treg cells (West, 2015). These cells are important for immune regulation. If these cells don’t mature properly, allergic reactions are more likely to occur throughout life.

    Development of the immune system is not the only way the gut microbiota helps protect us from disease. These bacteria produce many beneficial molecules. Polysaccharide A (PSA) produced by B. fragilis is another one of these beneficial
molecules. PSA plays a role in development of the immune system, but also reduces the risk of developing colitis by reducing inflammation (West, 2015). Aside from reducing inflammation, bacteria help provide a first line of defense from pathogenic bacteria that make it into our gut. The presence of beneficial bacteria causes our epithelial cells to produce secretory IgA (SIgA) (West, 2015). SIgA is important for keeping our epithelial junctions tight. By coating bacteria like Lactobacillus and Bifidobacterium with SIgA, they are able to form a biofilm and bind to the epithelial cells so pathogenic bacteria can’t bind (West, 2015). If bacteria can’t bind to these epithelial cells, they can’t get in to induce their effects. Thus, competition of bacteria is one reason why having a natural gut microbiota helps defend us from incoming pathogenic bacteria.

    Since the gut microbiota has a strong connection to the immune system, many gut diseases can be traced back to an alteration of the gut microbiota. One of the most common diseases is inflammatory bowel disease (IBD). IBD includes Crohn’s disease (CD) and ulcerative colitis (UC). Inflammation of the GI tract is the most underlying symptom in IBD diseases. CD is specifically characterized by periods of inflammation followed by periods of remission, with increasing severity and complication with each occurrence. Chronic CD can lead to thickening of the mucosa, decreased lumen diameter, and ulcers in the mucosal lining. UC is very similar to CD, but occurs mainly in the colon instead of the entire GI tract. UC also produces more uniform effects while CD alternates between healthy and inflamed areas. In both IBD diseases, a change in the major types of bacteria in the microbiota were found (Zhang, 2015). These results make sense due to the relationship gut bacteria have with the immune system and inflammation. Other diseases that have been linked to a change in gut microbiota include liver disease, diabetes, obesity, and heart disease (Zhang, 2015).

    GI disorders can be very serious and extremely uncomfortable. Many individuals with these disorders can experience abdominal pain, cramping, diarrhea, and bleeding. Prolonged symptoms can even lead to dehydration, malnutrition, and anemia. These symptoms can be very hard to deal with even if the person appears to be fine on the outside. I know somebody that was diagnosed with CD and he had a very hard time with it. He had to be extremely careful what he ate to help prevent flare ups. When he
did have a flare up, you could tell he was extremely uncomfortable and in a fair amount of pain. He was able to manage the disease better after being diagnosed though. Some things that can be done to manage symptoms are eating a healthy diet, consuming probiotics (supplemental or natural), performing regular exercise, reduction of stress, and reduced use of antibiotics. Antibiotics can be beneficial, but if they are abused can lead to death of healthy gut microbes. Having healthy gut microbes is the key to prevention of such diseases.

    The relationship between the brain and gut microbiota is more prevalent than previously thought. Gut microbes have a strong connection to the brain in what is commonly referred to as the brain-gut axis. The brain-gut axis is the way the brain and gut cross-talk so feelings can have an actual physiological effect on the digestive system. Some of these physiological effects in the digestive system can then transition back to the brain as feelings like nausea, satiety, and pain (Sudo, 2004). Sudo and his team (2004) have discovered that the gut microbiota plays an important role in the development of this brain-gut cross-talk. Other studies have also shown that gut microbiota can influence behavior, which helps support this theory (Smith, 2015).

    There are several things that bacteria due to help promote this cross-talk between the brain. The production of key metabolites like short-chain fatty acids (SCFAs) are important for the development of tight junctions in the blood-brain barrier, insulin signaling, and other signaling pathway functions (Puddu, 2014). SCFAs have also been found to play a role in diabetes and obesity. Another way the gut microbes affect the brain-gut axis is through hormones. Bacterial metabolites increase serotonin production from nearby colon epithelial cells (Smith, 2015). Serotonin can then be used as a neurotransmitter in the brain for things like sleep, mood, and appetite. Another important factor in the development of the brain-gut axis is the role the immune system plays. The immune system releases cytokines that can help regulate neurophysiology (Smith, 2015). Since a healthy gut microbiota is important for the development of the immune system, it is important for the brain-gut axis as well.

    The important and highly interconnected nature of the gut microbiota is clear. This is why maintaining a healthy and diverse microbiota becomes particularly crucial.
A healthy diet full of probiotics and prebiotics can be very beneficial in maintaining these
microbes. Good sources of probiotics include yogurt, tempeh, soft cheeses, and sourdough bread. There are also many probiotic supplements on the market that can help maintain a healthy bacteria level. Prebiotics are polysaccharides that aren’t digested by the human body that act as a food source for the bacteria. We generally refer to these prebiotics as fiber. Good sources of fiber include whole grains, legumes, fruit, and vegetables. These can also be found in supplemental form but the bioavailability of fiber is usually higher in natural sources. In addition to prebiotics and probiotics, a well balanced diet will help maintain a rich and diverse microbiota. All these things can help ensure the health of you and your ever so important gut microbiota.



References

Del Chierico, Frederica, et al. 2015. Phylogenic and Metabolic Tracking of Gut Microbiota during Perinatal Development. Plos One Vol. 10(9): 1-26

Microbes in the human body. (2015). The Marshall Protocol Knowledge Base (MPKB) Autoimmunity Research Foundation. Web.

Puddu, Alessandra, et al. 2014. Evidence for the Gut Microbiota Short-Chain Fatty Acids as Key Pathophysiological Molecules Improving Diabetes. Mediators of Inflammation Vol. 2014: 1-9

Smith, Peter A. 2015. The tantalizing links between gut microbes and the brain. Nature Vol. 526: 312-314

Sudo, Nobuyuki, et al. 2004. Postnatal microbial colonization programs the hypothalamic-pituitary-adrenal system for stress response in mice. The Journal of Physiology Vol. 558(1): 263-275.

West, C. E., Jenmalm, M. C., and Prescott, S. L. 2015. The gut microbiota and the development of allergic disease: a wider perspective. Clinical & Experimental Allergy Vol. 45: 43-53.

Zhang, Yu-Jie, et al. 2015. Impacts of Gut Bacteria on Human Health and Diseases. International Journal of Molecular Sciences Vol. 16(4): 7493-7519

Levi Myers
Biology of Disease
Curated Paper 2: Brains and Guts
10/28/2016

Brains and Guts

For this paper I would like to discuss some of the connections that I have bee able to make as they relate to different areas of my life. These past few weeks we have been talking about neurological and gastrointestinal diseases. We have been going over mechanisms of these diseases and applying them to some of the diverse symptomology that can be seen in the populous. We started out our discussions with neurological disease. The first connection I made was involved with a very common disorder in the United States called Alzheimer’s. Alzheimer’s disease (AD), is caused by the formation and accumulation of two proteins called A b amyloids and Tau. These proteins cause problems when one of two things happens. First there is excessive formation of these proteins and this is followed and compounded by the ineffective removal. As these proteins build up they interfere with the workings of the cortex and eventually lead to death. These plaques form and build up on the folds of the most external portion of the brain the cerebral cortex. As this pressure builds up it causes the death of the neural tissues. These proteins form in very specific regions of the brain and one of the first steps of the disease is the generation of the defective amyloid plaques that cover the folds of the brain. As these proteins form they take the space of the cortex and brain mass is lost. This results in the loss of many vital functions necessary for essential human interactions.
A few years ago my grandmother was diagnosed with Alzheimer’s disease. After a time of dealing with the disease she became incapable of living on her own and needed to be cared for. This responsibility fell on my family and she moved in with us.  Because of this I was able to see what this disease does first hand and studying it allowed me to understand some of the things I saw her do. There was one day this semester in particular where I was studying the pre frontal lobe with some of its associations and functions were. These generally deal with the long-term planning and higher thinking abilities. In my readings there was a study done on people who had gotten frontal lobotomies and they had a bunch of weird effects. These patients lost the ability to complete complex puzzles and were unable to perform multiple tasks at the same time. They were talk but these conversations tended to be short and long concepts tended to be too much for them to grasp. Similar effects happen to people who have this disease. My grandmother for example suffered from similar things. Early on in her disease there was almost no noticeable difference until we started talking about something new or the conversation was longer than 10 or 15 minutes. In these situations the flow of the conversations would be off. She would not be able to remember the direction of her thoughts. As her disease progressed it was obvious that she was loosing her ability to communicate. She slowly digressed from more complex language and concepts to short phrases and lower vocabulary. This continued until she was more or less unable to speak. This led me to research what parts of the brain were the most used in both spoken and interpretation of language. From my studies I was once again able to connect these memories with something that I studied called the Broca’s and Wernicke areas. These areas are used in the production and interpretation of speech. There are hosts of diseases that deal with problems in these areas such as Broca’s aphasia and where an individual is able to think of words but not able to speak them or they are jumbled and make no sense to the listener. However the words would make sense to the person speaking them. I was able to connect these things to our studies of Alzheimer’s.
After this we delved into the mysteries of gastrointestinal diseases that have been on the rise over the last few decades. In my studies I came across a couple of these diseases and made the following connections. First I studied about ulcerative colitis. This is a nasty disease that is very informative in its name. The patient will suffer from ulcers that occur in the lower regions of the large intestine or colon. While I was volunteering in the emergency department we would have people that came in with what the doctors called GI bleeds. I was a good friend with one of the physicians there and he told me that he could tell where in the GI tract a bleed would be just from the color of the stool. I pondered this at the time and the thought resurfaced as I was researching the gastrointestinal tract. After reading about ulcerative colitis I learned that blood would generally be darker the higher in the GI tract that the bleed starts. The heme of the blood gets destroyed and parts of it are reabsorbed in the intestines. The longer the blood is in the intestine the longer it has to become digested. This made the doctors comment finally come into focus. Another time in the Emergency department we had a patient that had had some head trauma and the doctor used lights to test the responsiveness of his pupils. I studied about something that I have never heard of before called the thalamocortical system. Almost all of the sensory information processed by the brain has a relay system that incorporates the thalamus and the cortex. These signals travel from the thalamus to the cortex and then back to the thalamus where other signals are sent. This is interesting in that when this connection is severed in any way the brain has a very hard time with communicating to the rest of the body. We learned about the connection pathways in the brain and this is one of the reasons that they do the test. If both pupils dilate then the connection is not in immediate danger if only one eye dilates then there is a big issue with the neuronal connections and they can expect cerebral damage.

            Lastly I had a friend in high school that had rather sever lactose intolerance. This problem while not life threatening caused him to have to make a lot of changes in his diet that reduce the side effects of eating things with large amounts of lactose. I learned from our discussions in class and from my reading that humans are the only mammals that continue to drink milk past their infancy. For most, the enzyme lactase is only substantially active during these early years. After this time the expression decreases. It so happens that about 70% of humans have an altered allele that allows for production of lactase throughout their lives.  Overall I was able to learn a lot from our studies and to make sense of the life that I have lived through making connections to scientific principle we talk about.
Sensory Changes and Morning Sickness in Pregnancy


Pregnancy is a life changing event where one or possibly more offspring develop in the body of a woman. With great care and a certain amount of time, the offspring will grow and develop into a healthy infant child. During the 9-month period from fertilization to birth, many changes occur to the developing fetus. Week by week, expecting mothers check the progressive changes of their baby using different resources to see whether this week their baby is the size of an avocado or a mango. Not only are there changes to the baby’s body during this 9-month period, but also to the pregnant mother’s body. Examples of the most common changes seen during pregnancy are a change in hormone levels, enlarged breast tissue, constipation, and lower extremity edema just to name a few. Some changes are just as common but have limited scientific support. Some of those changes take place in the brain and the gastrointestinal tract.  The changes in the brain have to do with altered sensory perception, which include particularly olfaction and gustation, and also food cravings and aversion. These changes with the senses also are said to have an effect on the GI tract by causing nausea and vomiting, or Morning Sickness (Quinlan et al.  2003). This paper will explore the changes pregnancy has on the brain related to sensory perception, and how those changes affect the gastrointestinal tract.

A considerable amount of subjective data suggests that the sense of smell of an expecting mother during pregnancy is heightened. One study suggests that the reason for this increase in smell is due to an evolutionary advantage. The increased sensitivity allows women to sense any kind of harmful substance that may harm the mother or her fetus. (Simsek et al.  2015). Another study supports the suggestion that sensitivity is increased, but also suggests that odor identification is not, and may even be decreased during pregnancy (Cameron, 2007).Compared to non-pregnant women, expecting mother’s ability to identify different odors is not improved. Women in their first trimester were able to identify certain smells similar to that of non-pregnant women, but some smells were not able to identify while non-pregnant women were, suggesting that odor identification is not improved and may be decreased during pregnancy (Cameron, 2007). Although women cannot identify odors, women in their first trimester rated odors as more intense than non-pregnant women. A scratch-n-sniff test was done where both pregnant and non-pregnant women scratched a paper revealing an odor, where the more scratches released more odor. Pregnant women scratched significantly less times than a non-pregnant woman suggesting enhanced sensitivity to odors (Simsek et al.  2015). Also, pregnant women were asked if certain smells are more sensitive now than before they were pregnant, a vast majority of them reported smells that were strong and then, interestingly, commented on the pleasantness or unpleasantness of each smell. This study suggests that during pregnancy, a women is more able to distinguish a smell as more or less pleasant (Cameron, 2007). Although the science supporting olfactory changes during pregnancy are mostly subjective data, it still supports the theory that pregnancy causes a change in olfactory function.

The scent that goes hand in hand with olfaction and is also altered during pregnancy is the sense of taste, or gustation. A change in taste perception is experienced by a majority of pregnant women, 93% of pregnant women according to a recent questionnaire study (Ochsenbein-Kolble et al.  2005). A study reported by Nihon et al was performed to test gustatory function in the first, second, and third trimester. 32 pregnant women participated with 30 non-pregnant women as controls. Measurements of gustatory thresholds using a filter paper disk test showed that pregnant women had significantly higher gustatory thresholds than non-pregnant women, with a significant decrease in gustatory function in the first trimester (Ochsenbein-Kolble et al.  2005). Certain foods have been reported to taste differently, why these foods taste different during pregnancy is still unclear (Nihon et al.  1996). Intensity of certain foods has been reported to increase during pregnancy. They described an increase in bitter and salty intensity during the first trimester, and then a reduction in the second trimester. During the second and third trimesters, they reported that they preferred a higher concentration of salt in their food, possibly due to their low sensitivity to salt during that phase of pregnancy which would also confirm their finding that intensity decreases in the second and third trimesters. When asked which taste was preferred during pregnancy that was not a preferred test before pregnancy, majority of the pregnant reported sour to be a desired taste, followed by salty (Nihon et al.  1996). Interestingly, regarding the sweet taste, Similar to studies testing olfactory function testing odor identification, gustatory function in taste identification decreased significantly during pregnancy, especially in the first trimester. 

One major side effect of the changes olfaction and gustation is nausea and vomiting. Altered sense of smell and taste are not the primary cause of nausea and vomiting (Quinlan et al.  2003) but it may exacerbate symptoms a pregnant woman is already displaying. The etiology of nausea and vomiting during pregnancy is still unknown but many possibilities have been investigated. One suggestion is the altered level of the hormone Progesterone. One study prescribed non-pregnant women progesterone, which resulted in complaints of nausea, and altered gastric motility, suggesting the changes in progesterone levels to be a possible cause. The more common supported cause of nausea and vomiting by people is the presence of human chorionic gonadotropin, or hCG( Quinlan et al.  2003), but another study showed no change in nausea and vomiting with detected hCG, hence the roles of hCG remain controversial. As far as nausea exacerbation, studies show that the increased olfactory sensitivity may cause episodes of nausea and vomiting. A combination of increased olfactory sensitivity with the increased ability to identify smells as pleasant or unpleasant increases the chances to sense unpleasant smells at high intensity, leading to nausea and vomiting (Bayley et al.  2002). A positive outcome with decrease gustation function is it limits the ability of the taste of food to cause nausea and vomiting which preserves nutrient intake and contribute to safe blood volume. (Quinlan et al.  2003). It also allows women to eat more foods that otherwise would not taste as good but are beneficial to the developing fetus.

Changes in senses can lead to nausea due to the unpleasantness of the smell and sometimes taste. These changes also contribute to certain food cravings and aversions, and sometimes non-food cravings. Food cravings are said to be “all in your head”, and there is science that actually supports that, it is literally controlled by three parts of the brain, the hippocampus, insula, and caudate (Bayley et al. 2002). About 90% of pregnant women claim to have food cravings and aversions (Demissie et al. 1998) which occur primarily in the first and third trimesters. Monitored brain activity of pregnant women with food cravings and aversion showed activity in parts of the brain that are also related to pleasure and addiction, suggesting a largely related neurologic component to cravings and aversion. Pica, which is the desire to eat non-food substances, is actually very common (Bayley et al 2002). Examples include soil, laundry detergent, clay, and baking soda just to name a few. This affects gastric and intestinal motility which will affect nutrient absorption, in turn affecting nutrient intake of the developing fetus which may cause potentially serious harm. Further research concerning this issue is needed, especially to improve maternal and fetal health outcomes.

These are some of the many changes an expecting mother goes through during pregnancy and they have a huge impact on maternal and fetal health. Their ability to identify certain smells decreases but their sensitivity to the smell increases, as well as their ability to identify a smell as pleasant or unpleasant. Also, their sense of taste decreases in intensity, which may allow women to increase needed nutritious intake that they otherwise would not eat, thus contributing to the health of the developing fetus. Also it counteracts the increased olfactory function to control possible episodes of nausea and vomiting which can lead to loss of nutrients and blood volume in the mother. Understanding the changes in sensory perception during pregnancy and its effect on the body will allow us to know more how to control the negative effects of it and take advantage of the positive effects. This ultimately to improve maternal and fetal health, and make pregnancy a positive life changing event.
































Works Cited


Bayley, T. et al (2002).  Food Cravings and Aversions During Pregnancy: Relationships with Nausea and Vomitingwww.sciencedirect.com, p.  45-51.

Cameron, E.L., (2007).  Measures of Human Olfactory Perception During Pregnancy.  Oxford Journals, p.  775-782.

Demissie, T et al. (1998).  Food Aversions and Cravings During Pregnancy: Prevalence and Significance for Maternal Nutrition in Ethiopia.  Food and Nutrition Bulletin, : http://www.unu.edu/unupress/food/V191e/begin.htm#Contents.

Nihon, J., Kaiho, G., (1996).  A Study of Changes in Gustatory Sense During Pregnancy.  PubMed, 1208-17.

Ochsenbein-Kolble, N., Hummel, T., Von Mering, R., Zimmerman, R., (2005).  Changes in Gustatory Function During the Course of Pregnancy and Postpartum. US National Library of Medicine, PubMed.

Quinlan, J.D., Hill, D.A., (2003).  Nausea and Vomiting of Pregnancy.  American Family Physician, Florida Hospital, 121-128.


Simsek, G.,  Bayar Muluk, N.,  Arikan, O.K.,  (2015).  Marked Changes in Olfactory Perception During Early Pregnancy: A Prospective Case-Control Study.  European Archives of Oto-Rhino-Laryngology, p.  627-630